RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-19a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Immunohistochemistry; Dual-luciferase reporter assay; etc.
Target
NA
Pathway
NA
PubMed ID
Title
"MiR-19a, -19b, and -26b Mediate CTGF Expression and Pulmonary Fibroblast Differentiation"
Year
2016
Function
"Activation of the mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinase ERK, c-Jun N-terminal kinase (JNK), and p38 contributed to ET-1- and thrombin-induced CTGF, a-SMA, and vimentin expression in WI-38 cell.MiR-19a, -19b, and -26b were candidate miRNAs of CTGF. ET-1 and thrombin reduced candidate miRNA levels, while Candidate miRNA overexpression significantly suppressed ET-1- and thrombin-induced CTGF expression and reduced a-SMA and vimentin expression in the WI-38 cells.."